Author

X. Varelas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

G. Ligresti· 2 shared N. Caporarello· 2 shared A. A. Raslan· 1 shared A. Babu· 1 shared A. Federico· 1 shared A. Hinds· 1 shared A. M. Bujor· 1 shared A. M. Diaz Espinosa· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersPathology

G. Ligresti

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Generation of human alveolar epithelial type I cells from pluripotent stem cells

C. L. Burgess, J. Huang, P. Bawa, K.-D. Alysandratos, K. Minakin, M. P. Morley, A. Babu, C. Villacorta-Martin, A. Hinds, B. R. Thapa, F. Wang, A. M. Matschulat, E. E. Morrisey, X. Varelas, D. N. Kotton

This study generates human alveolar epithelial type I cells from iPSCs by activating YAP signaling, revealing Hippo-LATS-YAP's role in their differentiation.

bioRxiv · Jan 19, 2023Cell Biology

Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell Regeneration

A. A. Raslan, T. X. Pham, J. Lee, J. Hong, J. K. Schmottlach, K. Nicolas, M. D. Taha, A. M. Bujor, N. Caporarello, A. Thiriot, U. H. von Andrian, S. K. Huang, R. F. Nicosia, M. Trojanowska, X. Varelas, G. Ligresti

This study uses single-cell transcriptomics to analyze aging-related changes in lung regeneration and fibrosis in mice, identifying age-associated cellular and molecular alterations.

bioRxiv · Jan 17, 2023Pathology

Inactivation of the Hippo Tumor Suppressor Pathway Promotes Melanoma

M. A. Vittoria, N. M. Kingston, E. Xia, R. Hong, L. Huang, S. McDonald, A. Tilston-Lunel, R. Darp, J. Campbell, D. Lang, X. Xu, C. J. Ceol, X. Varelas, N. J. Ganem

This study shows that the Hippo tumor suppressor pathway is activated in growth-arrested melanocytes, preventing melanoma development, and its inactivation allows BRAF-driven melanoma formation.

bioRxiv · May 4, 2021Cancer Biology

ZNF416 is a pivotal transcriptional regulator of fibroblast mechano-activation

D. L. Jones, J. A. Meridew, M. T. Ducharme, K. L. Lydon, K. M. Choi, N. Caporarello, Q. Tan, P. A. Link, A. M. Diaz Espinosa, Y. Xiong, J.-H. Lee, Z. Ye, H. Yan, T. Ordog, G. Ligresti, , D. J. Tschumperlin

This study identifies ZNF416 as a key transcriptional regulator that mediates fibroblast responses to matrix stiffness through chromatin accessibility and gene expression changes.

bioRxiv · Jul 23, 2020Cell Biology

Yap suppresses T cell function and infiltration in the tumor microenvironment

E. Stampouloglou, A. Federico, E. Slaby, S. Monti, G. L. Szeto, X. Varelas

This study shows that Yap inhibits T cell function and infiltration in tumors, and its inhibition enhances anti-tumor immunity.

bioRxiv · Jun 5, 2019Cancer Biology