L. Huang

Inter-domain flexibility in F-Box proteins revealed by integrative modeling

The paper uses integrative modeling to reveal inter-domain flexibility in F-box proteins, showing varying conformational dynamics across different F-box proteins.

G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs

This study shows that Gγ13 signaling in tuft cells is essential for resolving lung inflammation and promoting recovery after severe injury.

Tuft cells act as regenerative stem cells in the human intestine

The paper identifies four human tuft cell states, showing they function as radiation-resistant stem cells capable of regenerating the intestinal epithelium.

A genome wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α

The paper uses a CRISPR/Cas9 screen to identify calreticulin as a repressor of ATF6α signaling in the unfolded protein response.

miR-100 and miR-125b Contribute to Enhanced 3D Growth and Invasiveness and can be Functionally Transferred to Silence Target Genes in Recipient Cells

This study identifies miR-100 and miR-125b as regulators of 3D growth and invasiveness in cancer cells, showing they can be transferred extracellularly to silence target genes in recipient cells.

The Porcine Skin Microbiome Exhibits Broad Fungal Antagonism

This study characterizes the porcine skin microbiome, identifies antifungal bacterial isolates, and discovers novel fungal and bacterial species with potential for antifungal applications.

Evolution of plant cell-type-specific cis-regulatory elements

The paper constructs a single-cell chromatin accessibility atlas in rice and compares it across grass species to study the evolution of cell-type-specific cis-regulatory elements.

PRMT5 orchestrates EGFR and AKT networks to activate NFκB and promote EMT

This study identifies PRMT5's role in promoting EMT in neuroblastoma by regulating EGFR and AKT pathways, leading to NFκB activation and tumor growth.

"Two-Birds-One-Stone" Oral Nanotherapeutic Designed to Target Intestinal Integrins and Regulate Redox Homeostasis for Ulcerative Colitis Treatment

This paper develops an oral nanotherapeutic, OPNs@LMWH, that targets intestinal integrins and regulates redox homeostasis to treat ulcerative colitis, showing improved therapeutic efficacy and immune uptake.

A fungal RNA-dependent RNA polymerase is a novel player in plant infection and cross-kingdom RNA interference

This study identifies a fungal RNA-dependent RNA polymerase essential for cross-kingdom RNAi and pathogenicity in plant infection.

Single-cell Sequencing Highlights Heterogeneity and Malignant Progression in Actinic Keratosis and Cutaneous Squamous Cell Carcinoma

This study uses single-cell RNA-seq to analyze the progression from actinic keratosis to cutaneous squamous cell carcinoma, identifying key driver genes and tumor microenvironment interactions.

ROR2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma

This study identifies ROR2 as a regulator of cellular plasticity in pancreatic neoplasia, showing it promotes an aggressive PDAC phenotype and resistance to KRAS inhibitors.

A novel nested gene Aff3ir participates in vascular remodelling by enhancing endothelial cell differentiation in mice

This study identifies Aff3ir as a novel gene involved in endothelial cell differentiation by enhancing vascular stem/progenitor cell differentiation in mice.

Tracer-based metabolomics for profiling nitric oxide metabolites in a 3D microvessel-on-a-chip model

This paper develops a tracer-based metabolomics approach to measure NO metabolites in 2D and 3D endothelial models, showing that 3D models with unidirectional flow better mimic physiological conditions than 2D static cultures.

Mass spectrometry imaging links interxylary cork formation with phytochemical distribution in Scutellaria baicalensis

This study uses mass spectrometry imaging to show that interxylary cork formation in Scutellaria baicalensis correlates with spatial phytochemical distribution, revealing distinct flavonoid accumulation patterns in different root tissue decay stages.

Proximity Labeling Expansion Microscopy (PL-ExM) resolves structure of the interactome

PL-ExM combines proximity labeling and expansion microscopy to visualize 3D interactome structures and assess PL technique performance.

BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia

This study identifies BHLHE40 as a key driver of polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia, showing its role in limiting bacterial shedding.

The role of alternative polyadenylation in Epithelial-mesenchymal transition of non-small cell lung cancer

This study identifies alternative polyadenylation (APA) events in non-small cell lung cancer (NSCLC) that influence EMT and drug response, showing shorter 3-UTRs correlate with better chemotherapy outcomes.

Engineered immunomodulatory extracellular vesicles derived from epithelial cells acquire capacity for positive and negative T cell co-stimulation in cancer and autoimmunity

This study engineers extracellular vesicles from epithelial cells to express immunomodulatory proteins, showing they can induce both positive and negative T cell co-stimulation in cancer and autoimmunity.

Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in Staphylococcus aureus

This study identifies that mutations in PBP4 and GdpP synergistically confer high-level, broad-spectrum β-lactam resistance in mecA-deficient Staphylococcus aureus strains.

The origin, divergence and inter-subspecies hybridization of house mice (Mus musculus)

This study traces the origin, divergence, and hybridization of three house mouse subspecies using population genomic data, revealing divergence times and patterns of introgression across Eurasia.

Progressive community, biogeochemical and evolutionary remodeling of the soil microbiome underpins long-term desert ecosystem restoration

This study examines the long-term microbial changes in desert soil during ecological restoration, finding shifts in community structure, functional diversity, and biogeochemical cycles over 17 years.

A muscle hypertrophy-derived myokine reprograms the stromal vascular fractions differentiation towards thermogenic adipocytes in subcutaneous adipose tissue

This study identifies Thbs4 as a muscle-derived myokine that promotes the conversion of white to beige adipocytes in subcutaneous adipose tissue, improving metabolic health and protecting against high-fat diet-induced disorders.

The Discovery and Characterization of 1,4-Dihydroxy-2-naphthoic Acid Prenyltransferase Involved in the Biosynthesis of Anthraquinones in Rubia cordifolia

This study identifies and characterizes RcDT1, a prenyltransferase involved in anthraquinone biosynthesis in Rubia cordifolia, and shows its evolutionary origin from the ubiquinone pathway.

Population genomic analyses reveal extensive genomic regions within selective sweeps associated with adaptation and demographic history of a wheat fungal pathogen

This study uses population genomic analyses to identify genomic regions under selection and demographic history of the wheat rust pathogen Pst, revealing adaptation mechanisms and population size changes linked to wheat domestication and agriculture.

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

This study compares a novel VZV mRNA vaccine (ZOSAL) with Shingrix in mice and rhesus macaques, showing ZOSAL induces stronger T cell immunity and safety.

Comprehensive catalogs for microbial genes and metagenome-assembled genomes of the swine lower respiratory tract microbiome identify the relationship of microbial species with lung lesions

The paper constructs gene catalogs and metagenome-assembled genomes from the swine lower respiratory tract microbiome and identifies associations between microbial species and lung lesions.

circDesign Algorithm for Designing Synthetic Circular RNA

This paper introduces circDesign, an algorithm for designing synthetic circular RNA that improves stability and protein translation efficiency, demonstrated using rabies virus glycoprotein.

Tirzepatide inhibits tumor growth in mice with diet-induced obesity

Tirzepatide reduces tumor growth in obese mice by decreasing food intake and metabolic hormones, but not by directly inhibiting cancer cell proliferation.

The paradox of extremely fast evolution driven by genetic drift in multi-copy gene systems

The paper uses the GH model to analyze genetic drift in mammalian rDNA genes, finding that fixation times are faster than expected, suggesting stronger drift or adaptive evolution.