Author

N. J. Ganem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

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Organism:human· 5 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

M. A. Vittoria· 5 shared R. J. Quinton· 3 shared A. L. Manning· 2 shared C. J. Ceol· 2 shared N. Hermance· 2 shared R. Darp· 2 shared S. Lim· 2 shared A. Didomizio· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersCancer Biology

M. A. Vittoria

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5 papers

Recent·Most cited

Inactivation of the Hippo Tumor Suppressor Pathway Promotes Melanoma

M. A. Vittoria, N. M. Kingston, E. Xia, R. Hong, L. Huang, S. McDonald, A. Tilston-Lunel, R. Darp, J. Campbell, D. Lang, X. Xu, C. J. Ceol, X. Varelas, N. J. Ganem

This study shows that the Hippo tumor suppressor pathway is activated in growth-arrested melanocytes, preventing melanoma development, and its inactivation allows BRAF-driven melanoma formation.

bioRxiv · May 4, 2021Cancer Biology

Oncogenic BRAF Induces Whole-Genome Doubling Through Suppression of Cytokinesis

R. Darp, M. A. Vittoria, N. J. Ganem, C. J. Ceol

This study shows that oncogenic BRAFV600E induces whole-genome doubling by suppressing cytokinesis in melanoma cells and zebrafish models.

bioRxiv · Apr 8, 2021Cancer Biology

Whole genome doubling confers unique genetic vulnerabilities on tumor cells

R. J. Quinton, A. Didomizio, M. A. Vittoria, C. J. Ticas, S. Patel, Y. Koga, K. Kotynkova, J. Vakhshoorzadeh, N. Hermance, T. S. Kuroda, N. Parulekar, A. M. Taylor, A. L. Manning, J. D. Campbell, N. J. Ganem

The paper identifies genetic vulnerabilities in WGD+ tumor cells and shows that KIF18A is specifically required for their viability.

bioRxiv · Jun 18, 2020Cancer Biology

Identification of STK25 as a direct activator of LATS signaling

S. Lim, N. Hermance, T. Mudianto, H. Mustaly, I. P. M. Mauricio, M. A. Vittoria, R. J. Quinton, B. W. Howell, H. Cornils, A. L. Manning, N. J. Ganem

This study identifies STK25 as a novel activator of Hippo signaling by directly phosphorylating LATS, and shows its deletion is common in human cancers.

bioRxiv · Oct 1, 2018Cell Biology

A genome-wide miRNA screen identifies regulators of tetraploid cell proliferation

M. A. Vittoria, E. M. Shenk, K. P. O'Rourke, A. F. Bolgioni, S. Lim, V. Kacprzak, R. J. Quinton, N. J. Ganem

This study identifies 23 miRNAs that promote tetraploid cell proliferation by enhancing mitogenic signaling or inhibiting tumor suppressor pathways.

bioRxiv · Feb 19, 2018Cancer Biology