Author

A. Tokmakoff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:mechanistic / dynamical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. L. Ferguson· 2 shared B. Ashwood· 2 shared J. R. Sachleben· 2 shared M. S. Jones· 2 shared Y. Lee· 2 shared A. Antoszewski· 1 shared A. R. Dinner· 1 shared A. Radakovic· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

A. L. Ferguson

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3 papers

Recent·Most cited

Molecular insight into how the position of an abasic site and its sequence environment influence DNA duplex stability and dynamics

B. Ashwood, M. S. Jones, Y. Lee, J. R. Sachleben, A. L. Ferguson, A. Tokmakoff

The paper examines how the position and sequence environment of an abasic site affect DNA duplex stability and dynamics using spectroscopy and simulations.

bioRxiv · Jul 22, 2023Biophysics

Direct monitoring of the thermodynamics and kinetics of DNA and RNA dinucleotide dehybridization from gaps and overhangs

B. Ashwood, M. S. Jones, A. Radakovic, S. Khanna, Y. Lee, J. R. Sachleben, J. W. Szostak, A. L. Ferguson, A. Tokmakoff

This study measures the thermodynamics and kinetics of DNA and RNA dinucleotide dehybridization using infrared spectroscopy and simulations, revealing stabilization through stacking interactions and structural dynamics.

bioRxiv · Apr 10, 2023Biophysics

Insulin dissociates by diverse mechanisms of coupled unfolding and unbinding

A. Antoszewski, C.-J. Feng, B. Vani, E. H. Thiede, L. Hong, J. Weare, A. Tokmakoff, A. R. Dinner

This study uses molecular dynamics simulations to investigate insulin dimer dissociation mechanisms, revealing multipathway behavior with conformational selection and induced fit as limiting cases.

bioRxiv · Mar 16, 2020Biophysics