Author

J. R. Sachleben

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. L. Ferguson· 2 shared A. Tokmakoff· 2 shared B. Ashwood· 2 shared M. S. Jones· 2 shared Y. Lee· 2 shared A. Radakovic· 1 shared D. A. Drummond· 1 shared D. Kahan· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

A. L. Ferguson

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3 papers

Recent·Most cited

Molecular insight into how the position of an abasic site and its sequence environment influence DNA duplex stability and dynamics

B. Ashwood, M. S. Jones, Y. Lee, J. R. Sachleben, A. L. Ferguson, A. Tokmakoff

The paper examines how the position and sequence environment of an abasic site affect DNA duplex stability and dynamics using spectroscopy and simulations.

bioRxiv · Jul 22, 2023Biophysics

Direct monitoring of the thermodynamics and kinetics of DNA and RNA dinucleotide dehybridization from gaps and overhangs

B. Ashwood, M. S. Jones, A. Radakovic, S. Khanna, Y. Lee, J. R. Sachleben, J. W. Szostak, A. L. Ferguson, A. Tokmakoff

This study measures the thermodynamics and kinetics of DNA and RNA dinucleotide dehybridization using infrared spectroscopy and simulations, revealing stabilization through stacking interactions and structural dynamics.

bioRxiv · Apr 10, 2023Biophysics

Sequential Activation and Local Unfolding Control Poly(A)-Binding Protein Condensation

R. Chen, D. Kahan, J. Shangguan, J. R. Sachleben, J. A. Riback, D. A. Drummond, T. Sosnick

This study uses HDX-MS to reveal that Pab1 condensation involves sequential activation of its RRMs through partial unfolding, driven by thermodynamic specificity.

bioRxiv · Sep 21, 2022 · PreprintBiophysics