A. R. Dinner

Dynamics of activation in the voltage-sensing domain of Ci-VSP

This study uses molecular dynamics simulations and computational frameworks to elucidate the microscopic mechanism of voltage-sensing domain activation in Ci-VSP.

Volumetric microscopy of CD9 and CD63 reveals distinct subpopulations and novel structures of extracellular vesicle in situ in triple negative breast cancer cells

A unified model for the dynamics of ATP-independent ultrafast contraction

This study develops a minimal mathematical model to explain ultrafast contraction in ciliated protists, identifying three dynamic regimes based on chemical driving rates and inertia.

Actin filament alignment causes mechanical hysteresis in cross-linked networks

The paper investigates how actin filament alignment affects mechanical hysteresis in cross-linked networks by varying cross-linker concentration and properties.

Kinetic model of small RNA-mediated regulation suggests that a small RNA can regulate co-transcriptionally

The paper develops a kinetic model to study sRNA-mediated gene regulation, revealing co-transcriptional regulation and identifying binding as a rate-limiting step.

Insulin dissociates by diverse mechanisms of coupled unfolding and unbinding

This study uses molecular dynamics simulations to investigate insulin dimer dissociation mechanisms, revealing multipathway behavior with conformational selection and induced fit as limiting cases.

Transient intracellular acidification regulates the core transcriptional heat shock response

This study shows that intracellular acidification, not protein synthesis, is required for Hsf1 activation during heat shock in yeast.

Mechanical and kinetic factors drive sorting of F-actin crosslinkers on bundles

The paper investigates how mechanical and kinetic factors influence the sorting of F-actin crosslinkers on bundles, showing a non-monotonic dependence on polymerization rate.

Tuning molecular motor transport through cytoskeletal filament network organization

This study examines how the organization of cytoskeletal filament networks affects myosin II motor transport dynamics, showing predictable changes based on network microstructure.

Filament Rigidity And Connectivity Tune The Deformation Modes Of Active Biopolymer Networks

The paper shows how filament rigidity and connectivity in active biopolymer networks affect deformation modes, contractility, and anisotropy through experiments and simulations.

Biphasic growth dynamics during Caulobacter crescentus division

This study reveals a biphasic growth model in Caulobacter crescentus, showing a timer phase followed by an adder phase during cell division.