Neuronal mimicry generates an ecosystem critical for brain metastatic growth of SCLC
F. Qu, S. Cao, W. Michno, C. J. Madubata, A. Puno, A. P. Drainas, M. C. Lee, D. Yang, A. Toland, C. Kong, M. Das, M. M. Winslow, A. M. Pasca, J. Sage
This study shows SCLC cells mimic neurons to promote brain metastasis by recruiting astrocytes through factors like Reelin and SERPINE1.
bioRxiv · Aug 10, 2021 · PreprintCancer Biology