Author

M. C. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Ecology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. P. Drainas· 2 shared C. Kong· 2 shared J. Sage· 2 shared M. M. Winslow· 2 shared A. Holzem· 1 shared A. K. Githeko· 1 shared A. L. He· 1 shared A. M. Pasca· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

A. P. Drainas

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

K. Kumpornsin, T. Kochakarn, T. Yeo, M. Luth, R. D. Pearson, J. Hoshizaki, K. Schindler, S. Mok, H. Park, A.-C. Uhlemann, S. M. Cubel, V. Franco, M. Gomez-Lorenzo, F.-J. Gamo, E. Winzeler, , M. C. Lee

This study creates a mutator parasite of Plasmodium falciparum to enhance drug resistance discovery by increasing mutation rates and identifying resistance mechanisms.

bioRxiv · Aug 23, 2022 · PreprintMicrobiology

A multiplexed in vivo approach to identify driver genes in small cell lung cancer

M. C. Lee, H. Cai, C. W. Murray, C. Li, Y. T. Shue, L. Andrejka, A. L. He, A. Holzem, A. P. Drainas, J. H. Ko, G. L. Coles, C. Kong, S. Zhu, C. Zhu, J. Wang, , J. Sage

The paper develops a multiplexed in vivo approach to identify driver genes in SCLC using CRISPR/Cas9 and lentiviral barcoding, finding TSC1 as a robust tumor suppressor.

bioRxiv · Mar 28, 2022Cancer Biology

Neuronal mimicry generates an ecosystem critical for brain metastatic growth of SCLC

F. Qu, S. Cao, W. Michno, C. J. Madubata, A. Puno, A. P. Drainas, M. C. Lee, D. Yang, A. Toland, C. Kong, M. Das, M. M. Winslow, A. M. Pasca, J. Sage

This study shows SCLC cells mimic neurons to promote brain metastasis by recruiting astrocytes through factors like Reelin and SERPINE1.

bioRxiv · Aug 10, 2021 · PreprintCancer Biology

Larval ecology and bionomics of Anopheles funestus in highland and lowland sites in western Kenya

I. Debrah, Y. A. Afrane, L. E. Amoah, K. O. Ochwedo, W. R. Mukabana, D. Zhong, G. Zhou, M. C. Lee, S. Onyango, E. O. Magomere, H. Atieli, A. K. Githeko, G. Yan

This study examines the larval ecology and sporozoite infection rates of Anopheles funestus in highland and lowland sites in western Kenya, finding that man-made ponds are most abundant for larvae and proximity to houses is a key environmental factor.

bioRxiv · Aug 4, 2021Ecology

Zinc supplement augments the suppressive effects of repurposed drugs of NF-kappa B inhibitor on ACE2 expression in human lung cell lines in vitro.

M. C. Lee, Y.-K. Chen, Y.-J. Hsu, B.-R. Lin

This study shows zinc enhances the suppression of ACE2 by repurposed NF-kappa B inhibitors in human lung cell lines.

bioRxiv · Jan 27, 2021Cell Biology