Redirecting RiPP biosynthetic enzymes to proteins and backbone-modified substrates
J. A. Walker, N. Hamlish, A. Tytla, D. D. Brauer, M. B. Francis, A. Schepartz
This paper demonstrates that RiPP enzymes can incorporate backbone-modified monomers into proteins, creating sequence-defined chemical polymers with diverse non-alpha-amino acid subunits.
bioRxiv · Jan 5, 2022Biochemistry