Author

A. Velusamy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:DNA methylation· 1 Assay:flow cytometry· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

K. Salaita· 4 shared H. Ogasawara· 2 shared A. K. Foote· 1 shared A. Rashid· 1 shared A. V. Kellner· 1 shared B. Petrich· 1 shared B. R. Deal· 1 shared J. D. Combs· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiophysics

K. Salaita

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Measuring integrin force loading rates using a two-step DNA tension sensor

J. D. Combs, A. K. Foote, H. Ogasawara, A. Velusamy, S. A. Rashid, J. N. Mancuso, K. Salaita

This paper develops a DNA tension sensor to measure integrin force loading rates in live cells, revealing exponential decay in bond lifetime and localized high-force events at cell-substrate junctions.

bioRxiv · Mar 15, 2024Cell Biology

DNA Origami Tension Sensors (DOTS) to study T cell receptor mechanics at membrane junctions

Y. Hu, Y. Duan, A. Velusamy, S. Narum, J. Rogers, K. Salaita

This study develops DNA origami tension sensors (DOTS) to measure TCR mechanotransduction at immune cell junctions, revealing forces between 5-10 pN and dependencies on cell state and antigen properties.

bioRxiv · Jul 9, 2023 · PreprintBiophysics

Molecular Mechanocytometry Using Tension-activated Cell Tagging (TaCT)

R. Ma, A. Velusamy, A. Rashid, B. R. Deal, W. Chen, B. Petrich, R. Li, K. Salaita

The paper introduces TaCT, a method to fluorescently label cells based on molecular force through adhesion receptors, and demonstrates its use in fibroblasts and mouse platelets.

bioRxiv · Jan 10, 2023 · PreprintBioengineering

Unbreakable DNA tension probes show that cell adhesion receptors detect the molecular force-extension curve of their ligands

R. L. Bender, H. Ogasawara, A. V. Kellner, A. Velusamy, K. Salaita

The paper demonstrates that integrin receptors detect the molecular force-extension curve of their ligands, not just the magnitude of force.

bioRxiv · Apr 4, 2022 · PreprintBiophysics