C-terminal cysteines of HRas control Erk signaling and 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) mediated inhibition of myoblast differentiation.
S. S. Pundlik, S. S. Sahoo, A. Barik, M. A. Jaysingh, A. Venkateshvaran, R. G. H. Math, A. Ramanathan
This study shows that mutations in HRas C-terminal cysteines affect its subcellular localization and signaling, and that 15d-PGJ2 from senescent cells inhibits myoblast differentiation via HRas Cys184.
bioRxiv · May 20, 2023 · PreprintCell Biology