Author

M. A. Jaysingh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Barik· 2 shared A. Ramanathan· 2 shared R. G. H. Math· 2 shared S. S. Pundlik· 2 shared S. S. Sahoo· 2 shared A. Venkateshvaran· 1 shared A. Venkatesvaran· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

A. Barik

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Author profile →

2 papers

Recent·Most cited

Senescent cells inhibit muscle differentiation via the SASP-lipid 15d-PGJ2 mediated modification and control of HRas

S. S. Pundlik, A. Barik, A. Venkatesvaran, S. S. Sahoo, M. A. Jaysingh, R. G. H. Math, A. Ramanathan

This study identifies 15d-PGJ2, a lipid from senescent cells, as a mediator of muscle differentiation inhibition via HRas modification and MAPK-Erk activation.

eLife · Aug 28, 2024Peer-reviewedBiochemistry

C-terminal cysteines of HRas control Erk signaling and 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) mediated inhibition of myoblast differentiation.

S. S. Pundlik, S. S. Sahoo, A. Barik, M. A. Jaysingh, A. Venkateshvaran, R. G. H. Math, A. Ramanathan

This study shows that mutations in HRas C-terminal cysteines affect its subcellular localization and signaling, and that 15d-PGJ2 from senescent cells inhibits myoblast differentiation via HRas Cys184.

bioRxiv · May 20, 2023 · PreprintCell Biology