The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions
H. Siegfried, R. Le Borgne, C. Durieu, T. De Azevedo Laplace, A. Verraes, L. Daunas, J.-M. Verbavatz, M. L. Heuze
This study shows that VAPA is essential for cell motility by anchoring ER-PM contact sites to focal adhesions and maintaining PI(4,5)P2 levels at the plasma membrane.
bioRxiv · Oct 17, 2022Cell Biology