Author

H. Siegfried

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:proteomics· 1

Frequent Co-Authors

A. L. Rothman· 2 shared A. Srikiatkhachorn· 2 shared A. Waickman· 2 shared H. Friberg· 2 shared J. R. Currier· 2 shared K. Victor· 2 shared S. Fernandez· 2 shared T. Li· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

A. L. Rothman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The ER tether VAPA is required for proper cell motility and anchors ER-PM contact sites to focal adhesions

H. Siegfried, R. Le Borgne, C. Durieu, T. De Azevedo Laplace, A. Verraes, L. Daunas, J.-M. Verbavatz, M. L. Heuze

This study shows that VAPA is essential for cell motility by anchoring ER-PM contact sites to focal adhesions and maintaining PI(4,5)P2 levels at the plasma membrane.

bioRxiv · Oct 17, 2022Cell Biology

Temporally integrated single cell RNA sequencing analysis of controlled and natural primary human DENV-1 infections

A. Waickman, H. Friberg, G. Gromowski, W. Rutvisuttinunt, T. Li, H. Siegfried, K. Victor, M. McCracken, S. Fernandez, A. Srikiatkhachorn, D. Ellison, R. G. Jarman, S. Thomas, A. L. Rothman, T. Endy, J. R. Currier

The paper compares the transcriptional responses of controlled and natural primary DENV-1 infections using scRNA-seq, finding similar inflammatory responses but more pronounced suppression of translation and mitochondrial function in natural infections.

bioRxiv · Jul 16, 2020Immunology

Analysis of cell-associated DENV RNA by oligo(dT) primed 5' capture scRNAseq

M. A. Sanborn, T. Li, K. Victor, H. Siegfried, C. Fung, A. L. Rothman, A. Srikiatkhachorn, S. Fernandez, D. W. Ellison, R. Jarman, H. Friberg, I. Maljkovic Berry, J. R. Currier, A. Waickman

This study uses 5' capture scRNAseq to detect and quantify DENV RNA in infected cells, revealing viral sequence variability and identifying infected cell types.

Scientific Reports · Jun 3, 2020Peer-reviewedMicrobiology