Kasturi Haldar, Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response
E. A. Alpizar-Sosa, N. R. Binti Ithnin, W. Wei, A. W. Pountain, S. K. Weidt, A. M. Donachie, R. Ritchie, E. A. Dickie, R. J. S. Burchmore, P. W. Denny, M. P. Barrett
This study identifies genetic and metabolic changes in Leishmania mexicana lines resistant to amphotericin B, revealing mutations in sterol metabolism genes and altered oxidative stress responses.
bioRxiv · Dec 8, 2021 · PreprintMicrobiology