M. P. Barrett

Ovothiol is a redundant part of a complex thiol network in promastigote Leishmania mexicana

This paper shows that OvoA, an enzyme involved in ovothiol synthesis in Leishmania mexicana, is not essential for growth or infectivity but affects sensitivity to amphotericin B.

The bloodstream form of Trypanosoma brucei displays non-canonical gluconeogenesis

This study identifies a non-canonical gluconeogenesis pathway in Trypanosoma brucei by showing sustained metabolic flux despite gene knockouts, suggesting a unique enzyme is involved.

A conserved metabolic signature associated with response to fast-acting antimalarial agents

This paper identifies a conserved metabolic signature in malaria parasites exposed to fast-acting antimalarial drugs, suggesting a common mechanism of action.

Kasturi Haldar, Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response

This study identifies genetic and metabolic changes in Leishmania mexicana lines resistant to amphotericin B, revealing mutations in sterol metabolism genes and altered oxidative stress responses.

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential drug sensitivity

This study compares metabolism between Trypanosoma congolense and T. brucei, finding differences in glucose uptake, glycolytic endpoints, and drug sensitivity.

Fly stage trypanosomes recycle glucose catabolites and TCA cycle intermediates to stimulate growth in near physiological conditions

This study shows procyclic trypanosomes can use TCA cycle intermediates and glucose catabolites for growth in the fly midgut, expanding their metabolic flexibility.

Mammalian deubiquitinating enzyme inhibitors display in vitro and in vivo activity against malaria parasites and potentiate artemisinin action

This paper shows that mammalian deubiquitinating enzyme inhibitors inhibit malaria parasites in vitro and in vivo, and enhance artemisinin activity, offering a strategy to combat artemisinin resistance.

Diminazene resistance in Trypanosoma congolense is linked to reduced mitochondrial membrane potential and not to reduced transport capacity

This study investigates diminazene resistance in Trypanosoma congolense and finds that resistance is due to reduced mitochondrial membrane potential rather than reduced drug transport capacity.

Lipoic acid biosynthesis is essential for Plasmodium falciparum transmission and influences redox response and carbon metabolism of parasite asexual blood stages

Experimentally engineered mutations in a ubiquitin hydrolase, UBP-1, modulate in vivo resistance to artemisinin and chloroquine in Plasmodium berghei.

This study experimentally tests mutations in UBP-1 in Plasmodium berghei and shows they confer resistance to artemisinin and chloroquine.

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

This study identifies CLK1 as a novel drug target in Trypanosoma brucei by showing its essential role in kinetochore function and cell survival through kinase inhibition.

The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing

This paper investigates how the benzoxaborole AN7973 kills trypanosomes by inhibiting mRNA processing, identifying it as a viable drug target.