Author

P. W. Denny

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1

Frequent Co-Authors

K. Kalesh· 3 shared W. Wei· 2 shared A. M. Donachie· 1 shared A. W. Pountain· 1 shared B. S. Mantilla· 1 shared E. A. Alpizar-Sosa· 1 shared E. A. Dickie· 1 shared E. O. J. Porta· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

K. Kalesh

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Inhibition of HSP90 distinctively modulates the global phosphoproteome of Leishmania mexicana developmental stages

E. O. J. Porta, L. Gao, P. W. Denny, P. G. Steel, K. Kalesh

This study identifies how HSP90 inhibition differentially affects the phosphoproteome of Leishmania mexicana across life cycle stages, revealing distinct molecular responses in promastigotes and amastigotes.

bioRxiv · Jul 19, 2023 · PreprintMicrobiology

Transcriptome-wide identification of coding and noncoding RNA-binding proteins defines the comprehensive RNA interactome of Leishmania mexicana

K. Kalesh, W. Wei, B. S. Mantilla, T. I. Roumeliotis, J. Choudhary, P. W. Denny

This study identifies 2,417 RNA-binding proteins in Leishmania mexicana, including novel non-poly(A)-RNA-binding proteins, and reveals their roles in RNA-protein interactions and regulation of the protein kinome.

bioRxiv · Dec 8, 2021Microbiology

Kasturi Haldar, Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response

E. A. Alpizar-Sosa, N. R. Binti Ithnin, W. Wei, A. W. Pountain, S. K. Weidt, A. M. Donachie, R. Ritchie, E. A. Dickie, R. J. S. Burchmore, P. W. Denny, M. P. Barrett

This study identifies genetic and metabolic changes in Leishmania mexicana lines resistant to amphotericin B, revealing mutations in sterol metabolism genes and altered oxidative stress responses.

bioRxiv · Dec 8, 2021 · PreprintMicrobiology

A BONCAT-iTRAQ method enables temporally resolved quantitative profiling of newly synthesised proteins in Leishmania mexicana parasites during starvation

K. Kalesh, P. W. Denny

This paper introduces a BONCAT-iTRAQ method to profile newly synthesized proteins in Leishmania mexicana during starvation, identifying 166 NSPs and showing time-dependent changes in translation regulators.

PLOS Neglected Tropical Diseases · Dec 19, 2019Peer-reviewedMicrobiology