Author

A. Wijaya

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:metagenomics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. Ciulli· 2 shared D. Zollman· 2 shared W. Farnaby· 2 shared A. A. Lauber· 1 shared A. B. Frost· 1 shared A. Gollner· 1 shared A. Kroupova· 1 shared B. Kratochvil· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

A. Ciulli

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

A. Kroupova, V. A. Spiteri, H. Furihata, D. Darren, S. Ramachandran, Z. Rutter, S. Chakraborti, K. Haubrich, J. Pethe, D. Gonzales, A. Wijaya, M. Rodriguez-Rios, D. M. Lynch, W. Farnaby, M. Nakasone, , A. Ciulli

The paper introduces CRBNmidi, a Cereblon construct that enables high-resolution structural and biophysical studies of degraders without requiring DDB1 co-expression.

Nature Communications · Oct 15, 2024Peer-reviewedBiochemistry

Targeting cancer with small molecule pan-KRAS degraders

J. Popow, W. Farnaby, A. Gollner, C. Kofink, G. Fischer, M. Wurm, D. Zollman, A. Wijaya, N. Mischerikow, C. Hasenoehrl, P. Prokofeva, H. Arnhof, S. Arce-Solano, S. Bell, G. Boeck, , A. Ciulli

A single small molecule degrader targets 13 out of 17 prevalent oncogenic KRAS alleles, inhibiting growth of KRAS-driven cancer cell lines and inducing tumour regression in vivo.

bioRxiv · Oct 24, 2023Pharmacology & Toxicology

Systems-wide dissection of organic acid assimilation in Pseudomonas aeruginosa reveals a novel path to underground metabolism

S. K. Dolan, A. Wijaya, M. Kohlstedt, L. Gläser, P. Brear, R. K. Silva-Rocha, C. Wittmann, M. Welch

This study identifies a novel metabolic pathway in Pseudomonas aeruginosa for assimilating organic acids, revealing how enzyme promiscuity enables metabolic adaptation during infection.

bioRxiv · Aug 25, 2022Microbiology