Author

M. Nakasone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. Ciulli· 2 shared A. Kroupova· 1 shared A. Wijaya· 1 shared C. Crowe· 1 shared D. Darren· 1 shared D. Gonzales· 1 shared D. M. Lynch· 1 shared D. Zollman· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

A. Ciulli

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2 papers

Recent·Most cited

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

A. Kroupova, V. A. Spiteri, H. Furihata, D. Darren, S. Ramachandran, Z. Rutter, S. Chakraborti, K. Haubrich, J. Pethe, D. Gonzales, A. Wijaya, M. Rodriguez-Rios, D. M. Lynch, W. Farnaby, M. Nakasone, , A. Ciulli

The paper introduces CRBNmidi, a Cereblon construct that enables high-resolution structural and biophysical studies of degraders without requiring DDB1 co-expression.

Nature Communications · Oct 15, 2024Peer-reviewedBiochemistry

Mechanism of degrader-targeted protein ubiquitinability

C. Crowe, M. Nakasone, S. Chandler, M. H. Tatham, N. Makukhin, R. T. Hay, A. Ciulli

The paper solves cryo-EM structures of a degrader-mediated complex to reveal structural insights into target protein ubiquitination mechanisms.

bioRxiv · Feb 5, 2024Biochemistry