Author

A. Kroupova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

F. Ackle· 2 shared F. M. Boneberg· 2 shared J. Martinez· 2 shared M. Jinek· 2 shared A. Chui· 1 shared A. Ciulli· 1 shared A. Ferdigg· 1 shared A. Leitner· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiochemistry

F. Ackle

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Author profile →

3 papers

Recent·Most cited

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

A. Kroupova, V. A. Spiteri, H. Furihata, D. Darren, S. Ramachandran, Z. Rutter, S. Chakraborti, K. Haubrich, J. Pethe, D. Gonzales, A. Wijaya, M. Rodriguez-Rios, D. M. Lynch, W. Farnaby, M. Nakasone, , A. Ciulli

The paper introduces CRBNmidi, a Cereblon construct that enables high-resolution structural and biophysical studies of degraders without requiring DDB1 co-expression.

Nature Communications · Oct 15, 2024Peer-reviewedBiochemistry

Mechanistic basis for oxidative stress protection of the human tRNA ligase complex by the oxidoreductase PYROXD1

L. Loeff, A. Kroupova, I. Asanovic, F. M. Boneberg, M. M. Pfleiderer, A. Ferdigg, F. Ackle, J. Martinez, M. Jinek

The paper identifies how PYROXD1 protects the tRNA ligase complex from oxidative stress through structural and functional interactions.

bioRxiv · Apr 6, 2023 · PreprintBiochemistry

Molecular architecture of the human tRNA ligase complex

A. Kroupova, F. Ackle, F. M. Boneberg, A. Chui, S. Weitzer, M. Faini, A. Leitner, R. Aebersold, J. Martinez, M. Jinek

This study presents biochemical and structural analysis of the human tRNA ligase complex, revealing its molecular architecture and catalytic mechanism.

bioRxiv · Jul 11, 2021Biochemistry