Structural Capacitance in Protein Evolution and Human Diseases
C. Li, L. V. Clark, R. Zhang, B. T. Porebski, J. M. McCoey, N. A. Borg, G. I. Webb, I. Kass, M. Buckle, J. Song, A. Woolfson, A. M. Buckle
The paper identifies structural capacitance as a new mechanism in protein evolution that generates microstructure in disordered regions, linking it to disease and evolutionary adaptability.
bioRxiv · Feb 22, 2018Biochemistry