Author

L. V. Clark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

A. M. Buckle· 1 shared A. Woolfson· 1 shared B. T. Porebski· 1 shared C. K. W. Lim· 1 shared C. Li· 1 shared C. Saporito-Magrina· 1 shared G. D. McPheron· 1 shared G. I. Webb· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. M. Buckle

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Author profile →

2 papers

Recent·Most cited

CRISPR base editing of cis-regulatory elements enables target gene perturbations

C. K. W. Lim, T. X. McCallister, C. Saporito-Magrina, G. D. McPheron, R. Krishnan, M. A. Zeballos, J. E. Powell, L. V. Clark, P. Perez-Pinera, T. Gaj

This study shows CRISPR base editors can reduce gene expression by editing cis-regulatory elements, with examples in human and mouse models.

bioRxiv · May 26, 2022 · PreprintBioengineering

Structural Capacitance in Protein Evolution and Human Diseases

C. Li, L. V. Clark, R. Zhang, B. T. Porebski, J. M. McCoey, N. A. Borg, G. I. Webb, I. Kass, M. Buckle, J. Song, A. Woolfson, A. M. Buckle

The paper identifies structural capacitance as a new mechanism in protein evolution that generates microstructure in disordered regions, linking it to disease and evolutionary adaptability.

bioRxiv · Feb 22, 2018Biochemistry