Author

A. Worthington

Butler University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 6 Approach:experimental assay· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

C. Forsberg· 3 shared D. Poscablo· 3 shared T. Cool· 3 shared A. Beaudin· 2 shared S. Smith-Berdan· 2 shared A. Hussaini· 1 shared B. Manso· 1 shared C. Valencia· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

C. Forsberg

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Gene expression signatures of response to fluoxetine treatment: systematic review and meta-analyses

David G. Cooper, J. Paige Cowden, Patrick Vo, P.E. Stanley, Jack T. Karbowski, Victoria S. Gaertig, Caiden J Lukan, A. Worthington, Caleb A. Class

This paper conducts a systematic review and meta-analysis of gene expression data from fluoxetine treatment in humans and rodents to identify pathways associated with treatment response and resistance.

Molecular Psychiatry · Jul 17, 2025Peer-reviewedGenomics

An age-specific platelet differentiation path from hematopoietic stem cells contributes to exacerbated thrombosis

D. Poscablo, A. Worthington, S. Smith-Berdan, B. Manso, R. Adili, T. Cool, R. Reggiardo, S. Dahmen, A. Beaudin, S. W. Boyer, M. Holinstat, C. Forsberg

This paper identifies an age-specific platelet differentiation pathway from hematopoietic stem cells that contributes to thrombosis and platelet hyperreactivity in aging.

bioRxiv · Feb 23, 2024Cell Biology

Helicobacter chronic stage inflammation undergoes fluctuations that are altered in tlpA mutants

K. S. Johnson, C. Yang, J. E. Carter, A. Worthington, E. K. Robinson, R. Lopez Magana, F. Salgado, I. Arnold, K. M. Ottemann

This study shows that H. pylori chronic inflammation fluctuates over time, and tlpA mutants alter these dynamics without affecting colonization levels in later stages.

bioRxiv · Aug 1, 2022 · PreprintMicrobiology

Megakaryocyte Progenitor Cell Function is Enhanced Upon Aging Despite the Functional Decline of Aged Hematopoietic Stem Cells

D. Poscablo, A. Worthington, S. Smith-Berdan, C. Forsberg

This study shows that aging impairs hematopoietic stem cells but enhances megakaryocyte progenitor cell function and expansion.

Stem Cell Reports · Jun 1, 2021Peer-reviewedCell Biology

Interleukin 7 receptor (IL7R) is required for myeloid cell homeostasis and reconstitution by hematopoietic stem cells

T. Cool, A. Worthington, D. Poscablo, A. Hussaini, E. C. Forsberg

This study shows IL7R is essential for myeloid cell homeostasis and eosinophil reconstitution by hematopoietic stem cells in adult mice.

bioRxiv · Sep 2, 2020Immunology

The lymphoid-associated interleukin 7 receptor (IL-7R) regulates tissue resident macrophage development

G. Leung, T. Cool, C. Valencia, A. Worthington, A. Beaudin, C. Forsberg

This study shows that IL-7R regulates fetal-derived tissue-resident macrophage development through dynamic expression and progenitor-progeny relationships.

bioRxiv · Jan 30, 2019Immunology