Human Papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA
C. D. James, A. Youssef, A. Tadimari Prabhakar, R. Otoa, A. Witt, R. L. Lewis, M. L. Bristol, X. Wang, K. Zhang, R. Li, I. M. Morgan
This paper shows HPV16 replication converts SAMHD1 into a homologous recombination factor by phosphorylation, enhancing its recruitment to viral DNA and reducing replication.
bioRxiv · Nov 13, 2023Cancer Biology