Author

A. Tadimari Prabhakar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. D. James· 3 shared M. L. Bristol· 3 shared R. Otoa· 3 shared X. Wang· 3 shared A. Witt· 2 shared I. M. Morgan· 2 shared R. L. Lewis· 2 shared A. Dubey· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

C. D. James

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3 papers

Recent·Most cited

Fibroblast Stromal Support Model for Predicting Human Papillomavirus-Associated Cancer Drug Responses.

C. D. James, R. L. Lewis, A. L. Fakunmoju, A. Witt, A. H. Youssef, X. Wang, N. M. Rais, A. Tadimari Prabhakar, J. M. Machado, R. Otoa, M. L. Bristol

This paper develops a fibroblast co-culture model to predict drug responses in HPV+ cancers and shows it better predicts in vivo outcomes than in vitro alone.

bioRxiv · Apr 9, 2024Cancer Biology

Human Papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA

C. D. James, A. Youssef, A. Tadimari Prabhakar, R. Otoa, A. Witt, R. L. Lewis, M. L. Bristol, X. Wang, K. Zhang, R. Li, I. M. Morgan

This paper shows HPV16 replication converts SAMHD1 into a homologous recombination factor by phosphorylation, enhancing its recruitment to viral DNA and reducing replication.

bioRxiv · Nov 13, 2023Cancer Biology

Human papillomavirus 16 E2 interaction with TopBP1 is required for E2 and viral genome stability during the viral life cycle.

A. Tadimari Prabhakar, C. D. James, C. Fontan, R. Otoa, X. Wang, M. L. Bristol, R. D. Hill, A. Dubey, I. M. Morgan

This paper shows that HPV16 and HPV11 E2 proteins require interaction with TopBP1 for stability, and disrupting this interaction with CK2 inhibitors like CX4945 promotes viral genome integration and could be a therapeutic strategy.

bioRxiv · Jan 11, 2023Cancer Biology