CD4 T Cells Acquire Cytotoxic Properties to Modulate Cellular Senescence and Aging
Y. Elyahu, I. Feygin, N. Pinkas, A. Zemer, A. Shicht, O. Berner, E. Eremenko, A. Nemirovsky, K. Reshef, L. Roitman, V. Krizhanovsky, A. Monsonego
This study shows CD4 T cells differentiate into cytotoxic T cells in senescent-rich environments, and reducing senescent cells halts this differentiation, impacting aging and disease.
bioRxiv · Jan 14, 2024Immunology