Author

L. Roitman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:development & morphogenesis· 1 Research Focus:ecology & biodiversity· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

V. Krizhanovsky· 2 shared A. Agrawal· 1 shared A. Mayo· 1 shared A. Monsonego· 1 shared A. Nemirovsky· 1 shared A. Shicht· 1 shared A. Zemer· 1 shared E. Eremenko· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

V. Krizhanovsky

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

CD4 T Cells Acquire Cytotoxic Properties to Modulate Cellular Senescence and Aging

Y. Elyahu, I. Feygin, N. Pinkas, A. Zemer, A. Shicht, O. Berner, E. Eremenko, A. Nemirovsky, K. Reshef, L. Roitman, V. Krizhanovsky, A. Monsonego

This study shows CD4 T cells differentiate into cytotoxic T cells in senescent-rich environments, and reducing senescent cells halts this differentiation, impacting aging and disease.

bioRxiv · Jan 14, 2024Immunology

p16-dependent upregulation of PD-L1 impairs immunosurveillance of senescent cells

J. Majewska, A. Agrawal, A. Mayo, L. Roitman, R. Chatterjee, J. Kralova, T. Landsberger, Y. Katzenelenbogen, T. M. Salame, E. Hagai, N. Stanojevic, I. Amit, U. Alon, V. Krizhanovsky

This study identifies p16-dependent upregulation of PD-L1 in senescent cells as a mechanism to evade immune clearance, showing that anti-PD-L1 treatment can eliminate these cells.

bioRxiv · Jan 30, 2023 · PreprintCell Biology