A. Zilman

Mechanics limit ecological diversity and promote heterogeneity in confined bacterial communities

This study shows that mechanical interactions and spatial constraints in confined environments limit bacterial community diversity but allow stable heterogeneous populations, even with growth advantages.

Proofreading Is Too Noisy For Effective Ligand Discrimination

This study shows that kinetic proofreading reduces ligand discrimination resolution with more steps, contradicting the common belief that it improves discrimination.

Spatial exclusion leads to tug-of-war ecological dynamics between competing species within microchannels

This paper extends the Moran model to include spatial exclusion in microchannels, showing it alters fixation probabilities and fixation times compared to classical models.

Self-regulation of the nuclear pore complex enables clogging-free crowded transport

The paper constructs a computational model of the nuclear pore complex to explain how it avoids clogging and improves transport efficiency in crowded conditions.

Physical modelling of multivalent interactions in the nuclear pore complex

This study develops computational models to analyze the role of heterogeneity in FG Nups and NTRs, finding minor effects on binding equilibria but significant impacts on kinetics and multivalency.

Effects of Sequence Composition and Patterning on the Structure and Dynamics of Intrinsically Disordered Proteins

The paper investigates how sequence composition and patterning affect the structure and dynamics of intrinsically disordered proteins using coarse-grained simulations.

Molecular Counting with Localization Microscopy: A Bayesian estimate based on single fluorophore statistics

The paper develops a Bayesian method for molecular counting using localization microscopy, showing improved accuracy with multiple fluorophore labeling and applying it to quantify plasmid copy number variability in bacteria.