T. Zheng

The impact of Arctic environments on human cerebral blood flow

This study examines changes in cerebral blood flow in Arctic conditions and finds reduced velocity and increased pulsatility in specific arteries.

Expanding the molecular grammar of polar residues and arginine in FUS prion-like domain phase separation and aggregation

The paper expands the molecular grammar of polar residues and arginine in FUS prion-like domain phase separation and aggregation by showing additional residues contribute to these processes.

Site Effects in Multisite Fetal Brain MRI: Morphological Insights into Early Brain Development

This study identifies key MRI acquisition factors affecting fetal brain morphology and shows that ComBat-GAM harmonization effectively reduces site effects while preserving developmental patterns.

Structure and position-specific interactions of prion-like domains in transcription factor Efg1 phase separation

This study investigates the structural and interaction details of Efg1's prion-like domains during phase separation in Candida albicans, revealing helical structures and residue-specific interactions critical for the transcriptional switch between white and opaque cell states.

Longitudinal analysis of memory T follicular helper cells and antibody response following CoronaVac vaccination

This study tracks memory T follicular helper cells and antibody response after three doses of CoronaVac vaccine over 300 days, showing increased neutralizing antibodies and cTFH cells, with correlation between cTFH and antibody titers.

The Influence of Angiotensin II on the Gut Microbiome of Mice: Findings from a Retrospective Study

This study investigates how angiotensin II affects the gut microbiome in mice, finding its impact is smaller than factors like diet and facility.

Intra-Host Mutation Rate of Acute SARS-CoV-2 Infection During the Initial Pandemic Wave

This study quantifies the intra-host mutation rate of SARS-CoV-2 during acute infection and finds higher mutation rates in viruses with NSP-14 mutations and in immunocompromised patients.

GPR41/43 regulates blood pressure by improving gut epithelial barrier integrity to prevent TLR4 activation and renal inflammation

This study shows that GPR41/43 receptors regulate blood pressure by maintaining gut barrier integrity and preventing renal inflammation through TLR4 signaling.

Single-cell transcriptome analysis on the anatomic positional heterogeneity of pig skin

The paper analyzes single-cell transcriptomes of pig skin from six anatomical regions to characterize cellular heterogeneity and identify candidate genes for ECM accumulation.

Variability in Forest Plant Traits along the Western Ghats of India and Their Environmental Drivers at Different Resolutions

The paper maps plant trait variability across different spatial resolutions in the Western Ghats using imaging spectroscopy and identifies environmental drivers of trait variation.

A stable reference human transcriptome and proteome as a standard for reproducible omics experiments

The paper establishes a stable human cell line as a reference for transcriptomic and proteomic studies, showing consistent results across generations and platforms.

Self-regulation of the nuclear pore complex enables clogging-free crowded transport

The paper constructs a computational model of the nuclear pore complex to explain how it avoids clogging and improves transport efficiency in crowded conditions.

Multiplexed and millimeter-scale fluorescence nanoscopy of cells and tissue sections via prism-illumination and microfluidics-enhanced DNA-PAINT

This paper introduces PRIME-PAINT, a method for multiplexed fluorescence nanoscopy with millimeter-scale field-of-view and high resolution, demonstrating its use on biological samples.

Molecular insights into the effect of hexanediol on FUS phase separation

This study investigates how alkanediols, particularly 1,6-hexanediol, disrupt FUS phase separation using multiple techniques and identifies factors like geometry and hydrophobicity that influence their effectiveness.

A framework for multiplex imaging optimization and reproducible analysis

The paper introduces a framework and software for optimizing and reproducibly analyzing multiplex imaging data, focusing on cyclic immunofluorescence.

A tandem-repeat dimeric RBD protein-based COVID-19 vaccine ZF2001 protects mice and nonhuman primates

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

Previously uncharacterized interactions between the folded and intrinsically disordered domains impart asymmetric effects on UBQLN2 phase separation

This study identifies previously uncharacterized interactions between folded and disordered domains of UBQLN2 that asymmetrically modulate its phase separation behavior.

Recombinant chimpanzee adenovirus AdC7 expressing dimeric tandem-repeat RBD of SARS-CoV-2 spike protein protects mice against COVID-19

This study evaluates a recombinant chimpanzee adenovirus vaccine expressing a dimeric tandem-repeat RBD of SARS-CoV-2, showing enhanced immune responses and protection in mice.

Genome recombination-mediated tRNA up-regulation conducts general antibiotic resistance of bacteria at early stage

The paper shows that bacterial DNA recombination increases tRNA levels early in antibiotic stress, aiding resistance before efflux pumps or mutations.

The repertoire of testicular extracellular vesicles cargoes and their involvement in inter-compartmental communication required for spermatogenesis

This study isolates and characterizes testicular extracellular vesicles, identifies their cargo, and shows their role in inter-compartmental communication during spermatogenesis.

Quantitative proteomics links the LRRC59 interactome to mRNA translation on the ER membrane

The paper identifies the interactomes of ER ribosome-binding proteins, revealing distinct molecular environments and functional roles for SEC62 and LRRC59 in ER redox regulation and mRNA translation.

The dynamic surface proteomes of allergenic fungal conidia

This study identifies dynamic surface and secreted proteins of Aspergillus fumigatus conidia under different conditions and compares them to other allergenic molds.

High stretchability, strength and toughness of living cells enabled by hyperelastic vimentin network

This study shows that vimentin intermediate filaments provide cytoplasmic mechanics that enhance strength, stretchability, resilience, and toughness under severe deformations.