Author

A.-R. Carvunis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Evolutionary Biology· 4

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Organism:yeast· 3 Assay:DNA methylation· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

N. Vakirlis· 3 shared A. McLysaght· 2 shared O. Acar· 2 shared T. Ideker· 2 shared A. F. O'Donnell· 1 shared A. N. Hogan· 1 shared A. Wacholder· 1 shared B. Hsu· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersEvolutionary Biology

N. Vakirlis

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4 papers

Recent·Most cited

Ancestral Sequence Reconstruction as a tool to detect and study de novo gene emergence

N. Vakirlis, O. Acar, V. K. Cherupally, A.-R. Carvunis

This study evaluates Ancestral Sequence Reconstruction (ASR) as a tool to detect de novo genes by analyzing ~2,600 yeast genes and identifying 33 de novo emerged genes.

bioRxiv · Jan 2, 2024Evolutionary Biology

Quantitative translation of dog-to-human aging by conserved remodeling of epigenetic networks

T. Wang, J. Ma, A. N. Hogan, S. Fong, K. Licon, B. Tsui, J. F. Kreisberg, P. D. Adams, A.-R. Carvunis, D. Bannasch, E. A. Ostrander, T. Ideker

This study translates dog-to-human aging by identifying conserved epigenetic changes, showing methylation patterns align physiological milestones across species.

bioRxiv · Nov 19, 2019 · PreprintEvolutionary Biology

Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes

N. Vakirlis, A.-R. Carvunis, A. McLysaght

The paper estimates that sequence divergence accounts for at most a third of eukaryotic orphan genes using conserved synteny analysis across yeast, fly, and human.

bioRxiv · Nov 11, 2019Evolutionary Biology

De novo emergence of adaptive membrane proteins from thymine-rich intergenic sequences

N. Vakirlis, O. Acar, B. Hsu, N. Castilho Coelho, S. B. Van Oss, A. Wacholder, K. Medetgul-Ernar, J. Ianotta, A. McLysaght, C. J. Camacho, A. F. O'Donnell, T. Ideker, A.-R. Carvunis

This study shows that de novo emerging coding sequences in yeast often encode beneficial transmembrane proteins, suggesting that intergenic regions may contain pre-existing blueprints for such functions.

bioRxiv · Apr 29, 2019Evolutionary Biology