A. McLysaght

Evidence for increased stress resistance due to polyploidy from synthetic autotetraploid Caenorhabditis elegans

This study shows synthetic autotetraploid Caenorhabditis elegans exhibit increased stress resistance, particularly under cold stress, compared to diploids.

Extensive lineage-specific rediploidisation masks shared whole genome duplication in the sturgeon-paddlefish ancestor

The paper shows that shared whole genome duplication in the sturgeon-paddlefish ancestor is masked by lineage-specific rediploidisation, revealing a mosaic of shared and non-shared gene duplications.

De novo birth of functional, human-specific microproteins

The paper demonstrates that de novo gene birth can produce functional microproteins with significant phenotypic effects in humans and other animals.

Synteny-based analyses indicate that sequence divergence is not the main source of orphan genes

The paper estimates that sequence divergence accounts for at most a third of eukaryotic orphan genes using conserved synteny analysis across yeast, fly, and human.

De novo emergence of adaptive membrane proteins from thymine-rich intergenic sequences

This study shows that de novo emerging coding sequences in yeast often encode beneficial transmembrane proteins, suggesting that intergenic regions may contain pre-existing blueprints for such functions.