Blood-brain barrier dysfunction in aging induces hyper-activation of TGF-beta signaling and chronic yet reversible neural dysfunction
Vladimir V. Senatorov, A.R. Friedman, Dan Z. Milikovsky, Jonathan Ofer, Rotem Saar‐Ashkenazy, Adiel Charbash, Naznin Jahan, G. Chin, Eszter Mihaly, Jessica May Lin, Harrison J. Ramsay, Ariana Neelufar Moghbel, Marcela K. Preininger, Chelsy R. Eddings, Harland V. Harrison, , Daniela Kaufer
This study shows BBB dysfunction in aging leads to TGF-beta hyperactivation in astrocytes, causing neural dysfunction, which can be reversed by inhibiting TGF-beta signaling.
bioRxiv · Feb 1, 2019 · PreprintNeuroscience