Albert J. Becker

This study uses single-cell transcriptomics to show that BRAFV600E-driven glioneuronal tumors have distinct immune profiles based on tumor grade, with SPP1 playing a key role in high-grade tumors.

This study shows that gangliogliomas induce developmental changes in cortical networks, leading to seizure dynamics that shift from neonatal to adult stages, with age-specific therapeutic implications.

The paper identifies HIF1α as a regulator of CaV3.2 expression, linking hypoxia to neuronal hyperexcitability and epileptogenesis.

This study identifies SLK as critical for dendritic complexity and inhibitory synapse maintenance in neurons, with implications for human cortical malformations.

The paper demonstrates a CRISPRa/i toolbox for manipulating the Cacna1h gene promoter to study CaV3.2 channelopathies in neuronal cells and tissues.

This study identifies how PI3K/mTOR signaling and Trp53 loss determine the heterogeneity and excitability of BRAFV600E-induced brain tumors in mice.

The paper investigates glutamate spread in the neuropil using optical reporters and finds that glutamate can activate AMPA and NMDA receptors at distances up to 2 micrometers from the release site.

This paper introduces a CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency that mirrors human phenotypes, including cognitive impairments and epilepsy, and identifies synaptic transmission deficits.

The paper identifies daily oscillating transcripts in the hippocampus of control and epileptic mice, showing distinct circadian patterns and implications for drug timing.

This study shows BBB dysfunction in aging leads to TGF-beta hyperactivation in astrocytes, causing neural dysfunction, which can be reversed by inhibiting TGF-beta signaling.

This study examines the role of microdeletions in different epilepsy subtypes, finding enriched contributions in Genetic Generalized Epilepsy but not in Rolandic or Adult Focal Epilepsy.