Chelsy R. Eddings

Ultrastructural membrane dynamics of mouse and human cortical synapses

The paper uses zap-and-freeze electron microscopy to study synaptic vesicle dynamics in mouse and human brain slices, revealing conserved endocytic mechanisms.

Ultrafast endocytosis in mouse cortical inhibitory synapses

The paper shows that inhibitory synapses in mouse cortical neurons have ultrafast endocytosis depots similar to excitatory synapses, suggesting similar endocytic mechanisms.

Blood-brain barrier dysfunction in aging induces hyper-activation of TGF-beta signaling and chronic yet reversible neural dysfunction

This study shows BBB dysfunction in aging leads to TGF-beta hyperactivation in astrocytes, causing neural dysfunction, which can be reversed by inhibiting TGF-beta signaling.