Author

G. Chin

University of California, Berkeley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

A. Nayak· 1 shared A. Tomkinson· 1 shared A. Vijjapurapu· 1 shared A.R. Friedman· 1 shared Adiel Charbash· 1 shared Albert J. BeckeriD· 1 shared Alon FriedmaniD· 1 shared Andrew G. DilliniD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

A. Nayak

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2 papers

Recent·Most cited

Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4'-CN-4-Aza-7,9-Dideazaadenosine C-Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.

D. S. Siegel, H. C. Hui, J. Pitts, M. S. Vermillion, K. Ishida, D. Rautiola, M. Keeney, H. Irshad, L. Zhang, K. Chun, G. Chin, B. Goyal, E. Doerffler, H. Yang, M. O. Clarke, , R. L. Mackman

This paper describes the discovery and synthesis of GS-7682, a prodrug with broad antiviral activity against RSV and other viruses, showing efficacy in RSV-infected monkeys.

bioRxiv · Apr 17, 2024 · PreprintBiochemistry

Blood-brain barrier dysfunction in aging induces hyper-activation of TGF-beta signaling and chronic yet reversible neural dysfunction

Vladimir V. Senatorov, A.R. Friedman, Dan Z. Milikovsky, Jonathan Ofer, Rotem Saar‐Ashkenazy, Adiel Charbash, Naznin Jahan, G. Chin, Eszter Mihaly, Jessica May Lin, Harrison J. Ramsay, Ariana Neelufar Moghbel, Marcela K. Preininger, Chelsy R. Eddings, Harland V. Harrison, , Daniela Kaufer

This study shows BBB dysfunction in aging leads to TGF-beta hyperactivation in astrocytes, causing neural dysfunction, which can be reversed by inhibiting TGF-beta signaling.

bioRxiv · Feb 1, 2019 · PreprintNeuroscience