Quantifying RNA Folding Equilibria from Unclassified Cryo-EM Particle Images
Debanjana Maji, Lars Dingeldein, Minhuan Li, Miro A. Astore, Luke Evans, Wai Shing Tang, Jutta Rogal, Aaditya Rangan, Roberto Covino, Alex de Marco, Steve L. Bonilla, Pilar Cossio
This paper uses Bayesian ensemble reweighting on unclassified cryo-EM images to quantify RNA folding equilibria, showing agreement with bulk solution measurements.
bioRxiv · Oct 13, 2026 · PreprintBiochemistry