Lars Dingeldein

This paper uses Bayesian ensemble reweighting on unclassified cryo-EM images to quantify RNA folding equilibria, showing agreement with bulk solution measurements.

This paper introduces cryoSBI, a method using simulation-based inference to infer biomolecular conformations from cryo-EM images, achieving fast and accurate results.

The paper warns that counting particle images in cryo-EM can lead to biased estimates of conformational state populations due to noise and orientation uncertainty, and suggests using full image datasets for more accurate modeling.