Cancer BiologybioRxivPreprint
Cell enlargement causes mitotic errors and aneuploidy in cells that evade senescence after CDK4/6 inhibition
Aanchal Udaynath Pareri, Marialucrezia Losito, Floris Foijer, Adrian Thomas Saurin
The paper shows that CDK4/6 inhibitor-treated cells that evade senescence experience mitotic errors and aneuploidy due to cell enlargement, which can be rescued by restoring cohesion.
DOI 10.1101/2025.07.01.662622