Natural Antisense Transcript of Period2, Per2AS, regulates the amplitude of the mouse circadian clock
Rebecca Mosig, Allison N. Castaneda, Jacob C. Deslauriers, Landon P. Frazier, Kevin L. He, Naseem Maghzian, Aarati Pokharel, Camille T. Schrier, Lily Zhu, Nobuya Koike, John J. Tyson, Carla B. Green, Joseph S. Takahashi, Shihoko Kojima
This study experimentally shows that Per2AS regulates circadian clock amplitude through a negative feedback loop with Per2, without producing a protein.
bioRxiv · Jul 27, 2020Molecular Biology