Joseph S. Takahashi

This study shows Escherichia coli has an intrinsic timekeeping system that anticipates daily temperature cycles through rhythmic curli plaque formation.

This study shows that ascorbate and TET2 promote balanced hematopoiesis, which is essential for surviving malaria and reducing disease severity.

The paper reports that mice exhibit behavioral activity with ~14 and ~28 day periodicity, aligned with geomagnetic fluctuations from the Moon and Sun, independent of circadian rhythms.

This study shows that Nocturnin regulates mitochondrial NADP(H)/NAD(H) rhythms, affecting steroid rhythm amplitude and hepatic metabolism in mice.

This study shows that time-restricted feeding extends healthspan in both sexes and lifespan in male mice under normal dietary conditions.

This study identifies two stages of metabolic and transcriptomic changes during caloric restriction in mice, revealing adiponectin as a key integrator of systemic adaptation.

This paper introduces a cell-type-specific circadian reporter mouse to study circadian rhythms in intestinal cells, finding that enteric neurons show distinct entrainment properties to feeding schedules.

This study shows that the time of day affects cancer immunotherapy efficacy through a circadian clock-dependent chemokine axis in mice.

The paper shows that mosquito salivary gland and sporozoite gene expression cycles with the day-night rhythm, affecting malaria transmission.

The paper identifies extensive soma-soma plate-like contacts (ephapses) between SCN neurons that may enable synchronization without chemical or electrical synapses.

The paper shows that the molecular clock in the SCN is necessary but not sufficient for fear entrainment in mice, leading to mistimed circadian behavior.

The paper shows that endogenous circadian clock proteins form dynamic microbodies distinct from phase separation condensates, suggesting an enzyme-like mechanism in the circadian feedback loop.

This study shows that human CLOCK has extra-circadian functions in the neocortex, enhancing cognitive flexibility and neural connectivity through altered gene expression in excitatory neurons.

This study identifies MEF2C as essential for the biological responses to sleep loss, including gene expression changes and synaptic strength recovery.

This study experimentally shows that Per2AS regulates circadian clock amplitude through a negative feedback loop with Per2, without producing a protein.

This study shows CNOT1 enhances phosphorylation of CLOCK and BMAL1 via PKA, stabilizing them and inhibiting their transcriptional activity in the mammalian circadian clock.

The paper shows BMAL1 DNA binding is tissue-specific and regulates rhythmic transcription through enhancer-enhancer interactions in the mouse liver.

This paper introduces mean-variance QTL mapping to identify novel QTL for circadian activity and exploratory behavior in mice, showing its superiority over traditional interval mapping in detecting both mean- and variance-controlling QTL.

This study shows BMAL1 regulates astrocyte activation and function through cell-autonomous and non-cell-autonomous mechanisms, impacting neuronal survival and brain health.

The paper identifies a mutation in Slc2a4 (GLUT4) in mice that causes chronic fatigue-like behaviors through a forward genetic screen.