Author

Aaron Wolman

New York Genome Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:database / resource· 1 Approach:experimental assay· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Tuuli LappalaineniD· 2 shared Alejandra CerveraiD· 1 shared Alper GokdeniD· 1 shared Ana Vasileva· 1 shared Ferrán ReverteriD· 1 shared François AguetiD· 1 shared Ivan H. IossifoviD· 1 shared Johannes SchumacheriD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

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10 top collaborators · 25 mutual co-author links

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2 shared papersGenomics

Tuuli LappalainenORCID

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2 papers

Recent·Most cited

An autoimmune disease risk variant has a trans master regulatory effect mediated by IRF1 under immune stimulation

Margot K. Brandt, Sarah Kim-Hellmuth, Marcello Ziosi, Alper Gokden, Aaron Wolman, Nora Lam, Yocelyn Recinos, Zharko Daniloski, John A. Morris, Veit Hornung, Johannes Schumacher, Tuuli Lappalainen

This study identifies a risk variant for autoimmune disease that acts as a trans-eQTL regulating IRF1 under immune stimulation, demonstrating its causal role and mechanism.

PLoS Genetics · Jul 27, 2021Peer-reviewedGenomics

Modified penetrance of coding variants by cis-regulatory variation shapes human traits

Stephane E. Castel, Alejandra Cervera, Pejman Mohammadi, François Aguet, Ferrán Reverter, Aaron Wolman, Roderic Guigó, Ivan H. Iossifov, Ana Vasileva, Tuuli Lappalainen

The paper shows that cis-regulatory variation modifies the penetrance of coding variants, affecting disease risk in cancer and autism, and demonstrates this through experimental validation.

Nature Genetics · Aug 10, 2018Peer-reviewedGenetics