Marcello Ziosi

This study modulates gene dosage using CRISPR and examines nonlinear transcriptional responses to dosage changes in three master transcription factors, revealing non-monotonic effects and links to disease genes.

The paper identifies target genes and pathways of blood trait loci using CRISPR screens and single-cell RNA sequencing, revealing cis and trans regulatory effects of noncoding variants.

This study identifies a risk variant for autoimmune disease that acts as a trans-eQTL regulating IRF1 under immune stimulation, demonstrating its causal role and mechanism.

This study shows that Eiger, the Drosophila TNF, is required for Myc-mediated cell competition but acts independently of JNK signaling.

Integrating expression, allelic expression and splicing across tissues identifies rare variants with relevance to traits.

The paper introduces a CRISPR/Cas9-based assay to test regulatory effects of genetic variants and applies it to detect effects in eQTLs and nonsense-mediated decay.