Veit Hornung

This study identifies mitochondrial protein import as a pathway linking proteostasis failure to mitochondrial permeabilization, showing that Raptinal impairs protein folding and VBIT4 inhibits this process.

This study develops a CRISPR/Cas9 platform for editing primary human HSPCs to investigate HIV host factors and their impact on viral infection in vitro and in vivo.

This paper develops a vesicle-based CRISPR/Cas9 platform for efficient gene knockout in primary human myeloid cells, preserving viability and enabling downstream functional studies.

This study reports a novel mode of NLRP3 activation in zebrafish through cryo-EM structure analysis, revealing a distinct oligomeric arrangement and activation mechanism compared to humans.

scPortrait integrates single-cell images with proteomics and transcriptomics data to identify cancer-associated macrophage subpopulations and embed images into transcriptome atlases.

This study identifies AMPylation as a key regulator of PLD3 processing and catalytic activity, showing its role in neurodegenerative diseases like Parkinson's.

Prophet predicts cellular phenotypes from perturbations using transfer learning, outperforming baselines and enabling in silico screening for therapeutic discovery.

SPARCS enables genome-wide CRISPR screening for spatial cellular phenotypes by combining laser microdissection with deep learning, identifying key genes involved in autophagosome formation.

This study uses phosphoproteomics to identify CDKs' role in TNF signaling, revealing their importance in cytokine production and cell death prevention.

This study identifies a risk variant for autoimmune disease that acts as a trans-eQTL regulating IRF1 under immune stimulation, demonstrating its causal role and mechanism.

The paper identifies response eQTLs that modify genetic regulation during immune activation and shows their enrichment in autoimmune disease GWAS signals.