Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity
Yifan Wu, Yang Song, Jennifer Soto, Tyler Hoffman, Xiao Yan Lin, Aaron Zhang, Siyu Chen, Ramzi N. Massad, Xiao Han, Dongping Qi, Kun-Wei Yeh, Zhiwei Fang, Joon H. Eoh, Luo Gu, Amy C. Rowat, , Song Li
This study shows viscoelastic substrates enhance epigenetic remodeling and cellular plasticity in fibroblasts, improving reprogramming efficiency into neurons and pluripotent stem cells.
Nature Communications · Apr 30, 2025Peer-reviewedCell Biology