Luo Gu

Matrix Viscoelasticity Regulates the Stemness and Multilineage differentiation of Primary Neural Progenitor-Stem Cells in 3D

This study shows that matrix stress relaxation influences stemness and multilineage differentiation of neural progenitor-stem cells in 3D by modulating mechanotransduction pathways.

Disordered glass nanowire substrates produce in vivo-like astrocyte morphology revealed by optical diffraction tomography

This study uses optical diffraction tomography to show that disordered glass nanowire substrates induce in vivo-like astrocyte morphology in cultured rat astrocytes.

Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity

This study shows viscoelastic substrates enhance epigenetic remodeling and cellular plasticity in fibroblasts, improving reprogramming efficiency into neurons and pluripotent stem cells.

Uncovering Astrocyte Morphological Dynamics Using Optical Diffraction Tomography and Shape-based Trajectory Inference

This study uses optical diffraction tomography to analyze astrocyte morphology changes in postnatal rat cortical astrocytes over 7 days in vitro, revealing dynamic shape transitions and cellular composition shifts.

Substrate stiffness modulates the emergence and magnitude of senescence phenotypes in dermal fibroblasts

This study shows that substrate stiffness affects the development and strength of senescence features in fibroblasts, with mechanosensitive regulation of key biomarkers.