A metabolic checkpoint coordinates bacterial cell envelope biosynthesis and c-di-GMP signaling
Xuhui Zheng, Katayoun Daneshjoo, Angeli Shieh, Megan R. O’Malley, Aashi Shah, Matthew R. Parsek
This study shows that acetyl-CoA inhibits PDEs in Pseudomonas aeruginosa, linking cell envelope biosynthesis to c-di-GMP signaling and biofilm formation.
bioRxiv · Jun 12, 2026 · PreprintMicrobiology