Matthew R. Parsek

The paper investigates mutations in the DNA-binding domain of LasR, a LuxR homolog in Pseudomonas aeruginosa, finding some variants enhance regulation of RhlR-target genes but confer fitness defects.

This study shows that acetyl-CoA inhibits PDEs in Pseudomonas aeruginosa, linking cell envelope biosynthesis to c-di-GMP signaling and biofilm formation.

The paper shows how matrix chemistry in bacterial biofilms affects metabolism and fitness by modulating pyocyanin retention and electron transfer efficiency.