A non-canonical mechanism of GPCR activation
Alexander S. Powers, Aasma A. Khan, Joseph M. Paggi, Naomi R. Latorraca, Sarah Souza, Jerry Di Salvo, Jun Lu, Stephen M. Soisson, Jennifer M. Johnston, Adam B. Weinglass, Ron O. Dror
This study identifies a non-canonical mechanism of GPCR activation where agonists directly rearrange an intracellular loop to regulate signaling, with implications for drug design.
Nature Communications · Nov 16, 2024Peer-reviewedMolecular Biology