Alexander S. Powers

Mechanism of Gating and Isoform-Specific Inhibition in Renal CLC Chloride Channels

The paper investigates how BIM1 selectively inhibits CLC-Ka over CLC-Kb by analyzing cryo-EM structures and showing that interactions with a conserved lysine and dynamic gating-loop behavior underlie this selectivity.

APOE interacts with COX-2 on lipid droplets to modulate inflammatory lipid signaling

This study identifies APOE interacting with COX-2 on lipid droplets, showing APOE3 promotes and APOE4 suppresses COX-2 activity and prostaglandin production.

MedSAGE: Bridging Generative AI and Medicinal Chemistry for Structure-Based Design of Small Molecule Drugs

MedSAGE improves small molecule drug design by generating synthesizable, drug-like molecules with high predicted affinity and selectivity for therapeutic targets.

A non-canonical mechanism of GPCR activation

This study identifies a non-canonical mechanism of GPCR activation where agonists directly rearrange an intracellular loop to regulate signaling, with implications for drug design.

pTSara-NatB, an improved N-terminal acetylation system for recombinant protein expression in E. coli

The paper develops a bacterial N-terminal acetylation system using yeast NatB complex to acetylate -synuclein in E. coli.