Author

Adam B. Weinglass

Merck & Co., Inc., Rahway, NJ, USA (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:protein sequence· 1 Approach:statistical model· 1

Frequent Co-Authors

Aasma A. Khan· 1 shared Aileen Soriano· 1 shared Alexander S. PowersiD· 1 shared David G. McLaren· 1 shared Elsa Beyer KralliD· 1 shared Gireedhar VenkatachalamiD· 1 shared Haihong ZhouiD· 1 shared Hubert B. JosieniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Aasma A. Khan

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Author profile →

2 papers

Recent·Most cited

Discovery of an NRAS isoform and activation-state selective macrocyclic peptide

Kenneth K. Hallenbeck, Yunpeng Zhou, Hubert B. Josien, Songnian Lin, Aileen Soriano, Mayhood Todd, Jaclyn Robustelli, Xiaomei Chai, My Sam Mansueto, Gireedhar Venkatachalam, Ryan E. Loy, Peng‐Hsun Chase Chen, Huifang Yao, Haihong Zhou, Elsa Beyer Krall, , S. Adrian Saldanha

The paper identifies a macrocyclic peptide that selectively binds NRAS with isoform and activation-state specificity, but lacks membrane permeability and functional inhibition.

bioRxiv · Jul 31, 2026 · PreprintCancer Biology

A non-canonical mechanism of GPCR activation

Alexander S. Powers, Aasma A. Khan, Joseph M. Paggi, Naomi R. Latorraca, Sarah Souza, Jerry Di Salvo, Jun Lu, Stephen M. Soisson, Jennifer M. Johnston, Adam B. Weinglass, Ron O. Dror

This study identifies a non-canonical mechanism of GPCR activation where agonists directly rearrange an intracellular loop to regulate signaling, with implications for drug design.

Nature Communications · Nov 16, 2024Peer-reviewedMolecular Biology